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In each year, we observed that Brazil had the highest consumption during the second and third quarter while Mexico had the highest consumption between the fourth and first quarter. Results of the time series analysis of Brazil for all antibiotics and by therapeutic sub-group. Inappropriate use of antibiotics enhances the development of antibacterial resistance, which is an important public health issue. The observed effect on seasonality may be due to the reduction of self-medication with antibiotics for acute respiratory infections. Pharmacies nationwide must submit information electronically concerning drugs subject to the reporting national system [14]. View Article Google Scholar 8. None of the two countries carried out an information campaign to prevent the inappropriate use of antibiotics, but Mexico did a campaign to inform the public about the regulatory changes.

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