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CYP19 gene, encoding aromatase enzyme, is involved in the estrogen response pathway. Our population was relatively small and an evaluation of a larger number of women for a longer time may modify this results. Polymorphism in the CYP19 and AR genes-relation to bone mass and longitudinal bone changes in postmenopausal women with or without hormonal replace therapy: The Danisch osteoporosis prevention study. Genes involved in the estrogen metabolism such as the CYP19 gene and in the estrogenic response the ESR1 gene are possible contributors to the pathophysiological processes associated with osteoporosis 8 , 9. Such an incoherence may be explained considering that, based on real data, we have low values of the BMI variable related to high values of height and weight. In recent years, our understanding on the role of estrogens in both females and males has made great progress, with a considerable emphasis being focused on the regulation of the extragonadal estrogen biosynthesis 1.

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